After Weight-Loss Surgery, a Year of Joys and Disappointments

Even as the pounds fell away and their health improved, two patients contended with the feeling that life hadn’t changed as much as they’d hoped.

Most people believe that the operation simply forces people to eat less by making their stomachs smaller, but scientists have discovered that it actually causes profound changes in patients’ physiology, altering the activity of thousands of genes in the human body as well as the complex hormonal signaling from the gut to the brain.

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